It was approved for medical use in the United States in May 2018. It works by binding to rivaroxaban and apixaban. Severe side effects may include blood clots, heart attacks, strokes, or cardiac arrest. Ĭommon side effects include pneumonia and urinary tract infections. It has not been found to be useful for other factor Xa inhibitors. (Disulfide bridge: H7-H12, H27-H43, H108-L98, H156-H170, H181-H209, L16-L27, L21-元6, 元8-L47, L55-L66, L62-L75, L77-L90)Īnticoagulant reversal (factor Xa inhibitors)Īndexanet alfa, sold under the trade name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding.
TQKTGIVSGF GRTHEKGRQS TRLKMLEVPY VDRNSCKLSS SFIITQNMFC AGYDTKQEDAĬQGDAGGPHV TRFKDTYFVT GIVSWGEGCA RKGKYGIYTK VTAFLKWIDR SMKTRGLPKAĪNSFLFWNKY KDGDQCETSP CQNQGKCKDG LGEYTCTCLE GFEGKNCELF TRKLCSLDNGĭCDQFCHEEQ NSVVCSCARG YTLADNGKAC IPTGPYPCGK QTLER QEEGGEAVHE VEVVIKHNRF TKETYDFDIA VLRLKTPITF RMNVAPACLP ERDWAESTLM IVGGQECKDG ECPWQALLIN EENEGFCGGT ILSEFYILTA AHCLYQAKRF KVRVGDRNTE
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